Extended stability study of an extemporaneously analgesic solution of clonidine, ropivacaine and fentanyl

The aim of this work was to perform an extended stability study for the analgesic containing fentanyl, clonidine and ropivacaine in physiological saline solution 0.9% at different infusion sites, such as bags, epidural sets syringes. assessed by HPLC system equipped with a photodiode array detector set 210 nm. separation conducted on C18 column maintained 40˚C using isocratic mobile phase consisted buffer solution-methanol-acetonitrile (45:45:10, v/v/v). presence particulate matter pH each were also investigated. Twenty-four hours after preparation, formation one suspected product observed all drugs, 24 it concentration decrease (PVC syringes administration sets). values varied no more than 5% during particle observed. Conclusion: applied promoted detection unexpected peak hours. Based it, further studies are necessary determine data.